Rutin, a naturally occurring flavonol glycoside, has been widely employed in the prevention and treatment of chronic venous insufficiency. However, its poor aqueous solubility and low oral bioavail...
<p><strong>Tác giả:</strong> Hoàng Thị Diệu Hằng, Dao Anh Hoang, Nguyễn Ngọc Chiến, Nguyễn Thị Sen, Lương Thị Lan, Luyện Bích Phượng, Vũ Trường Duy, Trịnh Thị Khánh</p>
<p>Rutin, a naturally occurring flavonol glycoside, has been widely employed in the prevention and treatment of chronic venous insufficiency. However, its poor aqueous solubility and low oral bioavailability significantly limit its therapeutic potential. To overcome these challenges, we developed a nanosized rutin formulation using a ball milling technique aimed at reducing the particle size of raw rutin to enhance its dissolution profile. Spray-dried powders containing rutin nanoparticles were...</p>
<p>📄 DOI: <a href="https://doi.org/https://doi.org/10.63240/jmm-nimm.2026.4.456" target="_blank" rel="noopener">https://doi.org/10.63240/jmm-nimm.2026.4.456</a></p>
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